Rice Callus: A Side-Effect-Free Solution to Cancer?
Ramakrishna WusirikaAparna Deshpande
Why This Project Is Important
The use of rice callus (an undifferentiated mass of plant cells) with several other secondary metabolites could provide a side-effect-free cancer treatment. New lung, prostate, and breast cancer cases in the United States top over 600,000 per year. These three types of cancer are among the most deadly, but could possibly be treated with no side effects by rice callus.
Many natural products from different plant species, like curcumin (which is derived from turmeric), have been identified for the treatment of simple ailments, like treating skin problems. Recently, researchers have looked at plant-based treatments for more invasive human diseases as well. Only a few of these products, however, have proven effective against cancer based on clinical trials. The most promising plant-based treatment method found to date is rice callus.
The major drawback of most anticancer drugs is that they also affect healthy cells. Our previous experiments have shown that rice callus culture killed 83 percent of colon cancer cells and 95 percent of renal cancer cells, with little or no effect on normal cells. These results are far superior to anticancer drugs that are currently available, which cannot only target cancerous cells.
Unlike whole plants or individual plant tissues, callus suspension cultures can provide an unlimited supply of compounds without the limitation of differentiation and life span, which currently provide scientists with major hurdles when researching plant-based cancer treatments.
We aim to test different dilutions of rice callus culture for its ability to kill human lung, prostate, and breast cancer cells—the three most common types of cancer in the United States. If we can find an effective solution, we could—for the first time—offer an anticancer drug with minimal or no side effects.
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What Your Donation Can Help Us Do:
- Purchase materials for experiments, including cancerous cell lines and reagents
- Determine if rice callus is effective in targeting lung, breast, and prostate cancers